High Definition Disease Modelling Lab, Stem Cell and Organoid Epigenetics, IEO, European Institute of Oncology, IRCCS, 20141 Milan, Italy.;Department of Oncology and Hemato-oncology, University of Milan, 20122 Milan, Italy.;Human Technopole, V.le Rita Levi-Montalcini, 1, 20157 Milan, Italy..